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674 results found

Pre-clinical drug discovery against hexanucleotide repeat-containing C9orf72 toxicity using Caenorhabditis elegans and patient-derived induced motor neurons

A few years ago, Dr. Parker and researchers in his lab genetically engineered worms that mimicked human ALS through motor neuron degeneration and paralysis.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Québec
Start Date
2018

Examining the role of KCC2 in maintaining the balance between excitation and inhibition in ALS

Each muscle in the body receives electrical signals through motor neurons that will stimulate it to contract.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Québec
Start Date
2018

Characterizing Enterovirus Disruption of Autophagy as a Disease Mechanism for ALS

A group of viruses called enteroviruses can cause a variety of infectious illnesses that are usually mild with symptoms that may include fever, respiratory distress, flu-like muscle aches and rashes.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
British Columbia
Start Date
2018

Investigating the effects of C9orf72 haploinsufficiency on TDP-43 pathology in ALS

Normal cells have a “self-cleaning” process called autophagy that breaks down and clears out cellular waste, so the cell can function properly.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Ontario
Start Date
2018

MRI Biomarkers of Cerebral Degeneration in ALS and their Pathological Validation

A biological marker, or “biomarker” for short, is a measurable indicator associated with a disease state that helps determine risk, severity and response to therapy.


Grant type
Capacity building grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Trainee Program 2018
Province
Alberta
Start Date
2018

The Canadian Prospective Cohort Study to Understand Progression in Multiple Sclerosis (CanProCo)

Progression – or the steady worsening of disease and increase in disability – is a challenging reality faced by people affected by MS, and despite major advances in MS research, the mechanism of progression and the ways in which researchers and clinicians can track progression are still not fully understood.


Grant type
Platform grants
Area of Research
Neurodegeneration
Competition
MS Progression Cohort
Province
Ontario
Start Date
2018

Parent-therapist partnership to provide early, intensive exercise to enhance walking outcomes in children with perinatal stroke

Perinatal (around birth) stroke is devastating, because the effects are life-long.


Grant type
Team grants
Area of Research
Injury
Competition
Improving Health Outcomes and Quality of Life
Province
Alberta
Start Date
2018

Implementation of a Clinical Pathway for Acute Care of Pediatric Concussion: Uptake, Outcomes, and Health Care Impacts

Each year, 1-2 million children in North America suffer a concussion.


Grant type
Team grants
Area of Research
Injury
Competition
Improving Health Outcomes and Quality of Life
Province
Alberta
Start Date
2018

Stroke Recovery in Motion

One in six people worldwide will experience a stroke in their lifetime.


Grant type
Team grants
Area of Research
Injury
Competition
Improving Health Outcomes and Quality of Life
Province
Ontario
Start Date
2018

Translating research into practice: Investigating the impact of Alzheimer’s disease diagnostics in Canada

Alzheimer’s disease causes progressive neurological decline and substantially decreases the quality of life of the individuals with the disease and their caregivers.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Improving Health Outcomes and Quality of Life
Province
British Columbia
Start Date
2018