Funded Grants

In 97 per cent of ALS cases and nearly half of cases of frontotemporal dementia, the TDP-43 protein is misplaced to an area outside the cell nucleus of the motor neuron called the cytoplasm.

TDP-43 is a protein that behaves abnormally in the motor neurons of 97 per cent of people with ALS.

Neuroinflammation has been implicated in a diverse array of degenerative conditions, ranging from Multiple Sclerosis  to  Alzheimer’s  disease.

Neuropathic pain is a chronic pain disorder resulting from damage to the nerves.

Optogenetic strategies – the ability to activate normally light-insensitive neurons with light – are being used in clinical trials to restore light sensitivity to the retina of vision impaired patients.

Multiple Sclerosis (MS) is a disease where the immune system attacks the brain and spinal cord.

Dr Bambico proposes to test a new and potentially groundbreaking experimental technique called EC stimulation, which will enable researchers to influence the activity of different kinds of neurons in any part of the brain without the need of major brain invasive surgery or complex genetic techniques.

My time in the Courtine laboratory provided an opportunity to obtain hands-on experience in the application of scRNA-seq to understand the pathobiology of SCI, through two different projects.