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Gary Shaw , University of Western Ontario × Clear Filters

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Elucidating the basis for ubiquitination of misfolded ALS proteins by E3 ligase Enzymes

A pathologic feature in both sporadic and familial ALS patients is the presence of large neuronal inclusions enriched with misfolded proteins, including SOD1, TDP43 and FUS that are frequently modified with the small protein ubiquitin (Ub)

Project ongoing See Project & Researchers
Grant type
Team grants
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2023