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500 results found

Sex differences in the innate immune response associated with Parkinson’s Disease

Age is the most important risk factor for Parkinson’s Disease (PD), followed by sex, with a higher risk in males.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
Brain Canada-Women's Brain Health Initiative Expansion Grants: Considering Sex and Gender
Province
Québec
Start Date
2022

Development and testing of a system for remote ischemic conditioning in preparation for clinical trials in cerebral small vessel disease and pre-hospital stroke care

One in four strokes are caused by a condition called cerebral small vessel disease (CSVD). There are no approved treatments for CSVD.


Grant type
Team grants
Area of Research
Injury
Competition
Canadian Stroke Consortium-Brain Canada-Heart and Stroke Foundation of Canada 2022 Stroke Clinical Research Catalyst Grants
Province
Alberta
Start Date
2022

AID-ME: Artificial Intelligence in Depression – Medication Enhancement: A Randomized, Patient and Rater Blinded, Active-Controlled Trial of a DeepLearning Enabled Clinical Decision Aid for Personalized Depression Treatment Selection

We are testing a new digital mental health solution for physicians to better manage the treatment of depression.


Grant type
Team grants
Area of Research
Mental Health
Competition
Bell Let's Talk - Brain Canada Mental Health Research Program
Province
Québec
Start Date
2022

Investigating the neuronal function of a novel HNRNPA1 variant

While significant efforts have been made worldwide, the development of an effective therapy to significantly slow or halt amyotrophic lateral sclerosis (ALS) progression has remained elusive.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Québec
Start Date
2022

Exploring the involvement of TDP-43 SUMOylation in ALS pathogenesis

TDP-43 is an essential DNA/RNA binding protein at the epicenter of Amyotrophic Lateral Sclerosis (ALS).


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2022

Imaging a New ALS Biomarker in the Eye

Current biomarkers of ALS used by clinicians to help care for ALS patients have many drawbacks that may include cost, accessibility, and invasiveness of procedures.


Grant type
Team grants
Area of Research
Neurodegeneration
Competition
ALS Canada - Brain Canada Discovery Grants
Province
Ontario
Start Date
2022

A multi-centre, prospective, randomized, open-label, blinded endpoint (PROBE) controlled trial comparing acute cervical internal carotid artery stenting to no stenting during endovascular thrombectomy for anterior circulation stroke due to acute tandem occlusion: Endovascular Acute Stroke Intervention – Tandem OCclusion trial (EASI-TOC)

Ischemic stroke occurs when a person suffers a sudden blockage of an artery in their brain.


Grant type
Team grants
Area of Research
Injury
Competition
Canadian Stroke Consortium-Brain Canada-Heart and Stroke Foundation of Canada 2022 Stroke Clinical Research Catalyst Grants
Province
Québec
Start Date
2022

Adaptive Platform Trial to Investigate VArious ThErapies in Carotid-Associated Stroke (ACTIVATE-CAS)- Pilot Phase

Carotid disease accounts for 10% of ischemic strokes and has high rate of recurrence of up to 30%-50%(1, 2).


Grant type
Team grants
Area of Research
Injury
Competition
Canadian Stroke Consortium-Brain Canada-Heart and Stroke Foundation of Canada 2022 Stroke Clinical Research Catalyst Grants
Province
Manitoba
Start Date
2022

B2AD-Risk AFDAS – Evolution of Burden of AF, Biomarkers, Left Atrial Characteristics, Demographics, and Risk Factors in AF Detected After Stroke

Atrial fibrillation (AF) is the most common heart rhythm disorder.


Grant type
Team grants
Area of Research
Injury
Competition
Canadian Stroke Consortium-Brain Canada-Heart and Stroke Foundation of Canada 2022 Stroke Clinical Research Catalyst Grants
Province
Ontario
Start Date
2022

Developing a Magnetic Resonance Imaging (MRI) based pH Mapping Tool for Clinical Stroke Assessment

Acute ischemic stroke represents the vast majority of strokes.


Grant type
Team grants
Area of Research
Injury
Competition
Canadian Stroke Consortium-Brain Canada-Heart and Stroke Foundation of Canada 2022 Stroke Clinical Research Catalyst Grants
Province
Alberta
Start Date
2022