Alzheimer’s Disease (AD) affects many people and leads to memory loss and cognitive decline. It is linked to brain inflammation and changes in proteins like GFAP, which is usually found in support cells called astrocytes. Recent research has discovered that GFAP can also appear in neurons, potentially making these cells more vulnerable to damage. Understanding this abnormal GFAP presence could lead to new treatment options for AD. This study aims to explore why GFAP appears in neurons in Alzheimer’s Disease when it normally should not be present in these cells. We will try to understand its effects on neuron health, and test whether reducing GFAP can improve brain function. We believe that stopping GFAP buildup in neurons could prevent damage and enhance memory and cognition, leading to potential new treatments for AD.
