We are studying a type of brain tumour called glioblastoma (GBM), which is often fatal despite current treatments. Our team developed a new technique to analyze a specific part of the tumour’s molecular makeup and found three subtypes with different survival rates. One subtype, called “Ciliary,” stands out because of increased translation of genes related to a cell structure called the primary cilium, also called the “Signaling Antenna” of the cell. This structure plays a role in cancer signaling and resistance to treatment. Our research aims to better understand how GBMs regulate translation of cilia genes and how it affects resistance to therapy. The results could lead to new biomarkers and treatments for GBMs.
