Personalized Modeling and Optimization of Transcranial Temporal Interference Stimulation in Major Depressive Disorder
Depression affects nearly 2 million Canadians, and about one-third of patients do not find relief from current treatments, highlighting the need for new approaches. This project investigates a non-invasive brain stimulation method called transcranial Temporal Interference Stimulation (tTIS), which can precisely target deep brain regions, like the subgenual anterior cingulate cortex (sgACC), that are linked to treatment-resistant depression. Using personalized brain models and clinical trial data, the research examines how tTIS affects brain activity and symptoms and explores ways to tailor stimulation for each individual. By considering sex and gender differences, this work aims to develop safer, more effective, and personalized therapies that could bring relief to those who do not respond to standard treatments for depression.
