Mitochondria are cellular components which provide the energy required by the brain. Any alteration of these small engines can lead to brain disorders, but their role in dementia remains poorly understood. We developed a tool named mitoDREADD-Gs. MitoDREADD-Gs is a transmembrane receptor which can be expressed in brain mitochondria of animal models. Its activation triggers biochemical cascades within mitochondria leading to increased mitochondrial activity. Activation of mitoDREADD-Gs in the brain of mouse models of dementia reverses memory deficits. In this project, we will use this tool to characterize the specific events linking the higher mitochondrial activity and the rescue of cognitive performance. We will also identify the types of brain cells involved in the improved memory performance. Overall, this project will identify the early causes of dementia.
