Microglia are the brain’s immune cells, and their role is to protect the brain. Yet in Alzheimer’s disease, these cells are often found diseased as well. In a brain with Alzheimer’s disease, the microglia’s ability to provide instruction is defective. This study’s hypothesis is that restoring translation on microglia will restore their ability to restrain Alzheimer’s disease pathology. Many studies address microglia function by measuring cell instructions. This study will explore several experimental paradigms to examine the mechanisms and consequences of restoring translation in microglia responding to Alzheimer’s disease pathology. This research could open new treatment avenues to boost microglia’s protective roles.
